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Testosterone Propionate: Is It The Fastest Acting Testosterone?

Written by Author - Authors Medical experts of the National HRT Clinic - January 14, 2016

The testosterone propionate intramuscular injection is considered to be the fastest acting of the testosterone injections. This medication has a molecular formula of C3H5O2 and is a very small and short ester, oil based, bio-identical injectable testosterone compound.

Testosterone Propionate

Testosterone Propionate is the shortest ester of all the types of testosterone and has the shortest half life of 2 to 3 days. This means that it needs to be injected just about every other day (according to the doctor’s prescription) and this is the only way to get proper results. Testosterone Propionate once injected into the muscle is released quickly into the blood stream where it starts to work quickly.

Since the Testosterone Propionate half life is only approximately 2.5 days, it makes it necessary to inject this medication just about every other day. It may not be as convenient as some of the other brands of testosterone medication that have longer half lives. This is also the reason why this particular brand of testosterone medication is prescribed less than the others.

Is Testosterone Propionate Available In The U.S.

Testosterone Propionate is available in the United States with a doctor’s prescription only. A patient must be blood tested and diagnosed with a testosterone deficiency (or low T) first before being able to get a prescription written for the correct dosage of medication.Testing is mandated in the U.S. to be able to buy Testosterone Propionate. Any other way of getting the medication is illegal and unsafe.

In addition to a prescription and an individually created treatment plan, a patient must also be receiving medical supervision from the doctor in order for therapy to be legal. Other countries may also sell Testosterone Propionate, but it will never be legal without a diagnosis, prescription and medical supervision.

Difference Between Testosterone Propionate And Cypionate

The difference between Testosterone Propionate and Testosterone Cypionate will be shown in the chart below. Propionate is a fast acting, smaller ester, with a shorter half life and Cypionate is a slower acting, larger ester and has  much longer half life. Testosterone Propionate must be administered every two to three days and Testosterone Cypionate only needs to be administered every 12 days approximately.

Difference Between Testosterone Propionate And Cypionate

Testosterone Propionate Testosterone Cypionate
Oily liquid suspended in sesame oil Oily liquid
Molecular formula: C3H5O2 Molecular formula: C8H14O2
Fastest release time into the blood stream Slowest release time into the blood stream
Half life of 2.5 days Half life of 12 days
5 carbon esters smaller 8 carbon ester
Considered more painful to inject Considered less painful to inject
Works quickly in the blood stream Slower to take effect in the body
Needs to be injected often (every other day) Needs to be injected about every 12 days
Results can be seen much quicker Results take more time to show
  • Cypionate is an oily liquid suspended in sesame oil. It has a chemical formula of C8H14O2 and has the longest half life of 12 days than the other types of testosterone injections. It has the slowest release time and longest active time in the system, so it can be taken less often than the other two types. It is one carbon heavier than Enanthate as an 8 carbon ester chain and 5 carbon esters larger than Testosterone Propionate.
  • Propionate is the testosterone type of medication with the shortest active life and half life of only 2 to 3 days of the three types of testosterone injections to buy. It is an oily, colorless liquid with a chemical formula of C3H5O2. With only 3 carbon esters, it is the smallest ester chain of all the testosterone medications.

How To Use Testosterone Propionate

There are 10 steps listed here that must be completed to get the best testosterone propionate results before and after therapy. The steps have been prepared by experts to get the best benefits from the injectable testosterone medication with little to no side effects:


Read the instruction booklet that came in your Testosterone Propionate kit that was shipped to you. You should learn all about your injection device, how to sterilize your work area and yourself, how to prepare your injections for usage and how to inject the needle. You do not need to become overwhelmed; however, because clinical advisors are always available to assist you throughout the entire process.


Wash your hands thoroughly with soap and warm water. Clean the surface where you will prepare your injections with alcohol pads. You want to make sure that everything you use for your injections is sterile before beginning preparation.


The next step will be to take inventory of everything that was shipped to you in your Testosterone Propionate kit. Everything must be sealed including, needles, syringes, alcohol pads, bandages and your medication vials or pens should be unopened as well.

Your medication should look completely clear. There should not be any particles in it nor should it look murky or cloudy. If it does, do not use it.


Preparation of your needle and syringe will be your third step. You will pull open the top of the vial of your doctor prescribed Testosterone Propionate. You will see a rubber stopper that you must wipe from one end to another with an alcohol pad. This is done to wipe any bacteria away.


Twist one of the needles on tightly to the syringe. You will be told which needle to use. Do not throw away the cap from the needle because you will use it later to recap the needle for safety before you throw it away.


Pull back on the syringe’s plunger to pull as much air into the syringe as your prescription calls for. This stops negative pressure from forming. Press the needle into the vial, turn the vial over and pull out your prescribed dosage of Testosterone Propionate. This may take time, but when finished, pull out the needle from the syringe. Flick the needle with two fingers to remove air bubbles. Cap the needle, twist it off of the syringe and throw it in the sharps container.


Twist the second needle onto the syringe. This is the one you will use to inject your needles into to your muscle. When the needle is in the syringe, push the plunger to remove the air that you brought into the syringe in an earlier step. Put the needle and syringe to the side.


You will now pick your Testosterone Propionate injection site. Choose either your (1) buttocks, (2) deltoid or (3) thigh muscle for the insertion of your needle. (You will rotate spots with each injection.) Wipe the area in a circular motion with an alcohol pad to remove bacteria from the area.

Open a bandage and stick it to your hand. Inject your needle either slowly or quickly into the muscle. The speed of pushing the injection into the skin is a personal choice.


Press the plunger to remove all of the medication from the syringe into the muscle. It is very important to get the entire Testosterone Propionate injections dosage into your body for change to occur.

Hold the needle in the body for about 30 to 60 seconds after all the medication is removed and then take the needle out of the skin. Quickly cover the injection site with the bandage on your hand. You have completed your injection and you will follow your prescribed testosterone propionate injection schedule as for when you will perform your next injection.

STEP 10:

Cap your needle, twist it off the syringe and throw it away in your sharps container.

Again, please remember that these are general instructions on the process of how to use Testosterone Propionate. You will also have an instructions booklet with pictures and diagrams to follow. Additionally, your clinical advisor will be able to help you via telephone as much as you need.

Testosterone Propionate Results Before And After

It is wise for patients of testosterone replacement therapy to learn about what will or can happen to their bodies before and after testosterone replacement therapy with Testosterone Propionate. This means learning about the benefits and the side effects of the medication.

Becoming aware of the pros and cons does not mean that they will all happen to you. It is just smart to understand the possibilities so that if they do occur, you will be prepared.

Testosterone propionate benefits:

  • Increased energy
  • Increased stamina and endurance
  • Increased exercise capacity
  • Less fatigue, tiredness and apathy
  • Faster recovery time from physical activity
  • A heightened sexual libido and sexual functioning
  • Help with erectile dysfunction
  • Longer and stronger erections and orgasms
  • Better mental cognition and emotional stability
  • Less depression and anxiety
  • Less irritability, agitation and anger
  • Lessened mood swings
  • Better concentration and focus
  • Better ability to remember
  • Less foggy mental feeling
  • Less feelings of disorientation
  • Less body, muscle and joint pain
  • A healthier heart
  • Better sleeping patterns
  • Lower LDL cholesterol levels
  • Less risk for heart attack, atherosclerosis or stroke
  • Healthier and more attractive skin
  • Less facial wrinkles
  • Less balding and/or thinning hair
  • Weight loss (especially fat around the abdomen)
  • Lean muscle mass gain
  • Stronger bone mineral density
  • Less bone breaks or fractures
  • Less risk for developing osteoporosis

Testosterone propionate injection side effects:

  • Acne
  • Oily skin
  • Blemishes
  • Redness, itching, irritation or infection at injection site
  • Aggression
  • Depression
  • Anxiety
  • Irritability
  • Loss of concentration and/or focus
  • Shrinking testicles
  • Hair loss
  • Balding
  • Swelling, pain or tenderness in breasts
  • Blood clots
  • Increased hunger or thirst
  • Nausea
  • Vomiting
  • Diarrhea
  • Indigestion
  • Swelling of hands, legs, ankles, feet, mouth, tongue or throat
  • Heart palpitations
  • Difficulty breathing
  • Darker urine or stool
  • Blood in the urine or stool

Not all of these benefits or side effects will happen to all people. If anything out of the ordinary begins to occur during your therapy experience, you are advised to let your clinical advisor know right away. If a side effect seems more serious or bothersome, get help immediately from nearest emergency room. Never leave any side effect unattended.

How Long Does It Take For Testosterone Propionate To Kick in?

Many sources that claim Testosterone Propionate has a half life of approximately four days as opposed to others who say the half life is 2.5 days, say that the kick in time is two weeks. The honest response to the question of how long does it take for Testosterone Propionate to kick in will vary from man to man.

The average time it will take for a male; however, to see and feel a change in his body will be approximately two weeks when he is on a reputable therapy program. Patients must keep up with their prescriptions which will call for no more than three days between injections. This is how patients will continue to see growth and change in their bodies from Testosterone Propionate.

How And Where To Buy Testosterone Propionate

Follow the proper steps to get a safe and legal prescription for Testosterone Propionate from only a reputable testosterone replacement therapy clinic. This is the way that you will be as sure as you can be that your medications will be 100 percent pure, your prescriptions will be accurate and the medical supervision you will receive will keep you safe.

All prospective patients of TRT must:

  1. Have a first consultation with a clinical advisor
  2. Get blood tested, get a physical exam and fill out a medical history form online
  3. Must have their medical information analyzed by one of the licensed doctors who ordered the testing to take place
  4. Must be diagnosed with low T
  5. Must get a prescription written by the licensed doctor

These are the five simple steps for how to buy Testosterone Propionate injections properly, safely and legally in the U.S. They are mandated in the U.S. to participate in legal and safe TRT.

One should not expect the Testosterone Propionate injection price to be cheap though when they buy real, 100 percent authentic Testosterone Propionate medication.  Sources say that on the black market, which is where often times fake, tainted, impure and cheaply made, testosterone can be bought at prices ranging from $45 to $90 per 10 ml (100 mg per ml) vial.

When a patient buys real Testosterone Propionate from a reputable source with medical supervision and a full TRT program, the cost can be upwards of 10 times that of the online black market. It is important to remember what you are getting for your money though.

Is Testosterone Propionate available in the U.S.? Yes, and this is why it is never suggested that anyone ever buy Testosterone medication from anywhere else. The cost might be more from a clinic in the United States, but patients who purchase testosterone from reputable and well known sellers in the U.S. will get what they pay for. There will not be any worries about being scammed or about injecting fake or tainted solution in their bodies.

For more information about anything related to what is a Testosterone Propionate injection, please fill out our online contact form to speak to a clinical expert for free. We are here to help you decide what you believe is best for your health and well being.

Medically reviewed by   Reviewers National HRT Staff - Updated on November 21, 2023

Please note that the information provided in this article is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.


  1. Wikipedia
  2. Medical News Today
  3. The Effect of injections of testosterone propionate and cortisone acetate on glycogen depletion induced by epinephrine in different skeletal muscles Endocrinology, Volume 53, Issue 5, 1 November 1953, Pages 480–486,