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The Testosterone Propionate Cycle

Written by Author - Authors Medical experts of the National HRT Clinic - January 11, 2016

Learning how to use testosterone propionate to one’s advantage is essential for a positive outcome from this type of hormone replacement therapy. HRT is not to be used by athletes or bodybuilders looking to bulk up in size or strength as it can cause undesirable side effects.


The appropriate testosterone propionate cycle must be prescribed by a doctor in order to achieve the desired results from treatment. Testosterone propionate has a short half-life and is typically administered on a daily or every other day cycle.

The testosterone propionate dosage for each person will be based on individual needs as determined by a hormone replacement therapy specialist. More information on how dosing is decided will be provided in the next section.

Detailed information on how to take testosterone propionate will be outlined in the final section of this report.

Determining the Testosterone Propionate Dosage

The required testosterone propionate dosage will be determined by the doctor following a thorough review of blood analysis and physical examination. The two most common dosing methods are as follows:

  • 50 – 100 mg each day
  • 50 – 100 mg every other day

As part of the testosterone propionate cycle, the HRT doctor may also order testosterone cypionate or enanthate injections, human growth hormone therapy, or some other medication as required. Discuss the options for treatment, along with the goals and desired benefits with an expert before beginning any type of hormone replacement.

The ability to achieve positive testosterone propionate results lies in ensuring that all required prescribing steps were carried out before administering any medication. No one should even use any type of testosterone treatment without first undergoing blood testing and physical examination. Make certain that the doctor has been provided with a complete medical history to ensure that there are no preexisting conditions that could cause problems for Low T treatment.

How to Administer Testosterone Propionate

It is not difficult to learn how to use testosterone propionate. The medication is to be injected into a larger muscle, such as the buttocks or thigh. Gather all required supplies before proceeding with the treatment.

Here are the steps for how to take testosterone propionate:

  • Remove the medications from the refrigerator so that it can reach room temperature before use
  • Check the vial for signs of discoloration, separation, or crystals – do not use if anything out of the ordinary is noticed
  • Always wash hands with soap and water before proceeding
  • Remove the vial cap and use an alcohol prep wipe to clean the rubber stopper
  • Once the stopper has dried, open a syringe package and uncover the 18 G needle – set the cover aside for recapping
  • Gently pull the plunger back to draw the same amount of air as medication to inject into the empty syringe – this air will be emptied into the testosterone propionate vial
  • Hold the vial on a counter and insert the 18 G needle straight down into the stopper – slowly push plunger down and press the air into the vial
  • Gently turn vial upside down so that the needle tip is covered with the liquid and draw the plunger back slowly to fill the syringe with the prescribed amount of testosterone
  • Check for bubbles in the syringe and tap lightly to force them to the top to be pushed back into the vial before completely filling the syringe to the proper amount
  • Pull the needle out of the stopper and replace the vial on the counter
  • Recover the needle, remove it from the syringe and discard in a Sharps container
  • Insert an IM (intramuscular) needle onto the syringe
  • Clean the injection site with another alcohol wipe and let dry
  • Remove and set aside the needle cover and insert the needle into the muscle at a 90-degree angle, pulling back on the plunger to assure that there is no blood entering the syringe
  • Slowly push the plunger down until all of the medication has entered the muscle
  • Remove the needle, cover with the cap, and discard entire syringe unit with needle into Sharps container
  • Place testosterone back into the refrigerator

It is crucial to follow all prescribed directions in order to get the desired testosterone propionate results. The medical staff at National HRT is here to answer any questions about this or any other type of hormone replacement.

Medically reviewed by   Reviewers National HRT Staff - Updated on November 21, 2023

Please note that the information provided in this article is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.


  1. Wikipedia
  2. Effect of the estrous cycle on the action of testosterone propionate on the organ and body weights of female rates Walter Shilling G. L. Laquer
  3. Endocrinology, Volume 30, Issue 5, 1 May 1942, Pages 753–760The influence of testosterone propionate on thyroid function of immature rainbow trout, Salmo gairdneri Richardson David W.C.HuntJ.G.Eales