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Causes of Testosterone Deficiency

Testosterone deficiency may be caused by a number of different things, and this will also vary from males to females. There are those who suffer from this condition at birth, making it a congenital issue that will most often be dealt with at an early age. Other individuals acquire Low T – as it is also known – later in life.

Testosterone Deficiency

Understanding what causes testosterone deficiency may help with determining the best possible course of action to take. At National HRT®, our hormone replacement specialists deal with acquired testosterone decline in adults over thirty.

The primary, secondary, and tertiary causes of Low T will be discussed in the sections below. First we will take a look at lifestyle and other medical issues that do not necessarily fit into those categories, but may, in fact, contribute to this hormonal decline.

These include:

  • Aging
  • Obesity
  • Alcoholism
  • Chronic illness
  • Stress
  • Medications
  • Drug abuse
  • High blood pressure
  • COPD
  • Renal disease
  • Diabetes
  • Smoking

The following protocol is used for the diagnosis of low testosterone production:

  1. Each individual concerned about a possible testosterone decline will complete a comprehensive health history questionnaire.
  2. Blood testing will determine the free and total testosterone levels, along with some other crucial panels that will enable the doctor to make a proper diagnosis.
  3. A physical examination will help to rule out other possible medical conditions and provide some important information that will be used to determine the appropriate treatment.

Primary Cause of Testosterone Deficiency

When the cause of testosterone deficiency is primary in nature, it will most often be related to an issue with the testicles not being able to produce a sufficient amount of this hormone for the body’s varied needs.

There are a number of reasons why this could be, including:

  • Klinefelter’s syndrome – this congenital abnormality occurs when a male has one or more extra X chromosomes
  • Cancer treatment/chemotherapy/radiatio
  • Testicular injury
  • Undescended testicles
  • Normal aging
  • Hemochromatosis – too much iron being produced in the body
  • Mumps that involved the testicles

In women, the primary cause of Low T could be linked to:

  • Ovarian failure
  • Surgical removal of the ovaries
  • Ovarian cancer
  • Menopause

Secondary Cause of Testosterone Deficiency

Among the secondary causes of testosterone deficiency, we find issues dealing with the pituitary gland. It is here, that the signals that are required for the testes and ovaries to perform their actions and produce testosterone originate, that is, once this gland receives its signals from the hypothalamus.

Examples of the secondary cause of Low T include:

  • Inflammatory disease – tuberculosis, histiocytosis, and sarcoidosis may be secondary or tertiary, depending on whether the pituitary gland or hypothalamus are involved
  • Pituitary disorders
  • Medications
  • Pituitary or brain tumor
  • Decreased blood flow to the glands
  • HIV/AIDS – this can affect testosterone production through the testes, pituitary gland, or hypothalamus.
  • Anabolic steroid usage

Tertiary Cause of Testosterone Deficiency

The hypothalamus is the impetus behind the tertiary cause of the development of testosterone deficiency. It is here that hormones are secreted that provide signals to the pituitary gland to produce other such chemical messengers that complete the cycle by delivering their signals to the testes. As such, many of the reasons behind secondary and tertiary Low T are the same.

  • Kallmann syndrome – abnormal hypothalamus development
  • Injury to the hypothalamus

Blood testing and physical examination will often yield a fairly comprehensive idea as to what is the cause of the symptoms that are being exhibited. The doctors and medical staff at National HRT® provide treatment with testosterone therapy to men and women who can benefit from having their testosterone levels raised to an ideal state.

Please contact us for a free consultation over the phone if you are concerned about any type of hormonal imbalance or deficiency.