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Humatrope vs. Omnitrope: Is There a Difference?

Written by Author - Authors Medical experts of the National HRT Clinic - August 25, 2016

Omnitrope and Humatrope When HGH was first introduced for sale, several pharmaceutical companies brought their own brands to the marketplace. Prices for HGH injections in those early days were very high – often costing thousands of dollars a month.

By the May of 2006 when Omnitrope was approved for sale, prices had already begun to decline. In a comparison of Humatrope vs. Omnitrope today, we continue to see a significant difference.

Sandoz, the maker of Omnitrope, is committed to providing people with high-quality medications at affordable prices.

Is there a difference in quality between Omnitrope and Humatrope?

That subject was the basis for research done back in 2014 regarding switching to Omnitrope from other brands of recombinant human growth hormone. Because children are the foremost users of growth hormone, the evaluation was done on those with one of the following conditions:

  • Growth hormone deficiency (GHD)
  • Idiopathic short stature (ISS)
  • Turner Syndrome (TS)

During the study time between January of 2006 and July of 2011, patients were switched from another brand of HGH to Omnitrope.

Inclusion in the study required participants to be under 18 years of age at the time of the switch and on HGH therapy for a minimum of 15 months. They then received Omnitrope for a minimum of 15 additional months following the switch. The results showed that growth trajectories were not negatively influenced by switching to Omnitrope.

What does this study mean for you, as an adult?

It shows that in a comparison of any high-quality brand of HGH such as Genotropin or Humatrope, Omnitrope performs just as well. You can save money and receive superior human growth hormone replacement therapy to treat adult GH deficiency.

In a study comparing Omnitrope to other brands of recombinant HGH, Omnitrope did just as well – and at a lower price.

Dosage difference between Humatrope and Omnitrope

Because all our recommended brands of HGH are similar in quality, the primary difference is how they are supplied. A comparison of Omnitrope vs. Humatrope shows that Eli Lilly, the manufacturer of Humatrope, offers three different injector pens along with 5 mg vials:

  • HumatroPen 6 mg
  • HumatroPen 12 mg
  • HumatroPen 24 mg
  • Humatrope 5 mg vials

Sandoz, the maker of Omnitrope, offers the following options:

  • Omnitrope Pen 5 mg
  • Omnitrope Pen 10 mg
  • Omnitrope 5.8 mg vials

What is the difference between the Humatrope vs. Omnitrope pens?

Humatrope InjectionsHumatroPens come in three different sizes. The 24 mg pens benefit those individuals who need a higher daily dose of HGH. Each of the three pen systems is a reusable injector that comes with replaceable cartridges.

You must use the correct-sized cartridge with its corresponding pen system. They are color-coordinated for consistency.

The Humatrope cartridges contain lyophilized (freeze-dried) HGH powder that must be reconstituted before the first use of the cartridge. Included in the Humatrope HGH kit are separate diluent syringes for each cartridge.

You will use one pre-filled syringe to reconstitute (mix) the HGH solution before inserting it into the HumatroPen device.

Humatrope requires continual refrigeration both before and after reconstitution.

Omnitrope Pens also feature replaceable cartridges that require refrigeration. The primary difference is that Omnitrope cartridges are premixed and in liquid form. You do not have to reconstitute them before use.

Both Humatrope and Omnitrope vials contain lyophilized HGH powder. After reconstitution, you can use these products with standard insulin needles and syringes.

Although both Humatrope and Omnitrope offer pen injector systems with replaceable cartridges, only Omnitrope is premixed in liquid form.

Do Humatrope and Omnitrope provide different results?

In a comparison of benefits between Humatrope vs. Omnitrope, you can expect to achieve the same results. The only thing that Omnitrope treats that Humatrope does not is Prader-Willi Syndrome. Both medications are indicated for the treatment of adult growth hormone deficiency.

According to a 2014 report comparing Omnitrope vs. Humatrope and other brands of rHGH, Omnitrope shows an 80% bioavailability compared to 75% for Humatrope administered subcutaneously.

Humatrope also states it can be administered intramuscularly (which we do not recommend). IM availability for Humatrope was only 63%. Genotropin has the same level of bioavailability at Omnitrope.

Ultimately, the choice comes down to this – price and convenience. Since both brands of HGH provide the same benefits, it is up to you to decide which one is best suited to your needs.

Of course, if cost is the primary factor, you will always do best with buying HGH in vials rather than injector pens. Your preparation time each day will only vary by a minute or two once you get accustomed to giving yourself the shots.

Both Humatrope and Omnitrope offer superior results. Brand selection is a matter of choice, price, and convenience.

Medically reviewed by   Reviewers National HRT Staff - Updated on March 20, 2023

Please note that the information provided in this article is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.