2475 Mercer Avenue, Suite 101
West Palm Beach, FL 33401
Get FREE Consultation

Testosterone Deficiency and Anemia


Anemia is defined as a deficiency of hemoglobin (red blood cells) in the body, and for older adults, it is often brought on by testosterone deficiency.

Poor dietary habits, illnesses, menstrual blood loss, and testosterone levels can all play a role in the onset of anemia.

What is the connection between testosterone deficiency and anemia in older men and women?

The hormone testosterone plays many roles in the body – it is not just a sex hormone.

Testosterone is crucial for the production of red blood cells. When Low T is present, a decline in red blood cell production often occurs.

In one study of 905 adults over the age of 65, it was discovered that those in the lowest range of testosterone level had the higher risk of anemia. [1]

These test results were the same for both bioavailable testosterone and total testosterone, as well as for men and women.

Role of Testosterone in Red Blood Cell Production

Red Blood Cell Production

The production of red blood cells is called erythropoiesis.

Testosterone, in its role as an androgen hormone, increases the production of erythropoietin, a hormone produced by the kidneys that stimulates erythropoiesis.

Testosterone also stimulates the responsiveness to the effects of erythropoietin on the immature bone marrow cells.

Additionally, testosterone regulates iron homeostasis.

Benefits of Testosterone Therapy for Anemia

Benefits of Testosterone Therapy for Anemia

Testosterone replacement therapy is good for more than improving libido or lean muscle mass (Useful ). Adults with Low T can benefit from the increase in red blood cell production to reverse the effects of anemia.

Further information from the afore-mentioned study brings up the concern that anemia in older persons is often associated with a higher risk of disability and accelerated physical function decline.

The study of 905 individuals contained 396 men of whom 31 had anemia at baseline (20 with no evident cause), and 509 women with 57 diagnosed with anemia (26 with no evident cause). Those participants with anemia had a greater incidence of stroke history than those without anemia, as well as lower testosterone levels – independent of age.

Since fatigue is common with both anemia and low testosterone, it should immediately be a red flag to anyone who finds that a lack of energy is affecting his or her life.

Testosterone replacement therapy not only increases energy and endurance, but it also stimulates the hormone erythropoietin that will help produce red blood cells.

You can find out if you have low testosterone by contacting the hormone specialists at National HRT for a confidential consultation at no charge. Affordable treatment options are available for women and men with Low T or other hormone deficiencies.


  1. Testosterone deficiency is a cause of anemia and reduced responsiveness to erythropoiesis-stimulating agents in men with chronic kidney disease. Carrero JJ1, Bárány P, Yilmaz MI, Qureshi AR, Sonmez A, Heimbürger O, Ozgurtas T, Yenicesu M, Lindholm B, Stenvinkel P Nephrol Dial Transplant. 2012 Feb;27(2):709-15. doi: 10.1093/ndt/gfr288. Epub 2011 May 26.
  2. Medical news bulletin
  3. Renal&Urology news
  4. Testosterone treatment improves bone density and anemia, may lead to cardiac risk Studies show benefits, risks of testosterone treatment in men over 65 February 21, 2017
  5. The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women Zahra Nikzad, Mina Iravani , Parvin Abedi, Nahid Shahbazian, Amal Saki Published: December 6, 2018
  6. Could Testosterone Replacement Therapy in Hypogonadal Men Ameliorate Anemia, a Cardiovascular Risk Factor? An Observational, 54-Week Cumulative Registry Study Li Tao Zhang Ji Yong Kim Jong Kwan Park J October 16, 2015